Prostate Dose Escalation by Innovative Inverse Planning-Driven IMRT
Abstract
The goal of this project is to develop innovative inverse planning techniques for prostate radiation therapy. In the last funding period significant progress has been made toward the goal of the project. In the past funding year, the PI group has contributed greatly to advance prostate radiation therapy techniques. A few important milestones have been achieved toward the goal of the project. These include: (i) Investigated intrafraction prostate motion and its influence on prostate radiation therapy; (ii) Developed method for auto-propagation of contours from planning CT to CBCT for on-line/off-line inverse planning; (iii) Established a novel technique to enhance on-board cone-beam CT and to effectively reduce the radiation dose incurred in the scanning process; (iv) Setup a framework for adaptive inverse planning based on a voxel specific penalty scheme; (v) Evaluated the feasibility of using on-board cone-beam CT for on-treatment dose calculation and developed a reliable electron density mapping algorithm for CBCT-based IMRT optimization; and (vi) Provided a robust procedure for retrospective dose reconstruction in IMRT dose delivery. These works are both timely and important and should have measurable impact on prostate cancer management.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 01, 2007
- Accession Number
- ADA483354
Entities
People
- Lei Xing
Organizations
- Stanford University