Cell Delivery System for Traumatic Brain Injury

Abstract

We have met all of the milestones outlined in this grant, except demonstration that the electrospun conduit supports cell growth. Composite gels are a more promising method for the brain patch therapy due to greater degree of control over shape of the three-dimensional structure, therefore the majority of our efforts have been focused on gel development. In addition to the work outlined in the original proposal, we have also determined a method for assessing diffusion of growth factors out of our gel matrices. Characterization of the release kinetics of neural-specific growth factors from gel matrices will help to inform the design of an appropriate growth-factor laden matrix for the cell delivery system.

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Document Details

Document Type
Technical Report
Publication Date
Mar 21, 2008
Accession Number
ADA483401

Entities

People

  • Elizabeth Orwin
  • Isabella Wulur
  • Madineh Sarvestani
  • Nicole Esclamado

Organizations

  • Harvey Mudd College

Tags

Communities of Interest

  • Human Systems

DTIC Thesaurus Topics

  • Biological Factors
  • Brain Injuries
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Confocal Microscopy
  • Culture Techniques
  • Electron Microscopy
  • Freeze Drying
  • Medical Personnel
  • Microscopes
  • Microscopy
  • Peptide Growth Factors
  • Peptides
  • Proteins
  • Stem Cells
  • Three Dimensional

Fields of Study

  • Medicine

Readers

  • Breast cancer cell signaling and growth regulation.
  • Nanocomposite Materials Science
  • Neurotrauma and Rehabilitation Medicine.