Structural and Functional Analysis of CA125: Potential for Early Diagnosis and Understanding the Immune Evasion Strategies of Epithelial Ovarian Tumors

Abstract

The proposed studies will define the structure and the biological function of the epithelial ovarian tumor marker MUC16 (CA125). The knowledge obtained can be utilized to develop better diagnostic tests for early detection of ovarian cancer and also to understand the pathogenesis of this disease. Due to delays in procuring the appropriate approvals from the Institutional Review Boards we have not been able to initiate the proposed studies. Research on MUC16 in the PI's laboratory has continued, however, through the use of start-up funds provided by the University of Wisconsin-Madison. This research has led to a very in-depth understanding of the MUC16 molecule and its physiological relevance. The impact of this understanding on the proposed studies will be significant. Here, we briefly discuss the highlights of this research effort.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2006
Accession Number
ADA483461

Entities

People

  • Manish S Patankar

Organizations

  • University of Wisconsin–Madison

Tags

DTIC Thesaurus Topics

  • Amniotic Fluid
  • Biomedical Research
  • Blood
  • Cancer
  • Cell Line
  • Cells
  • Department Of Defense
  • Functional Analysis
  • Institutional Review Board
  • Lymphocytes
  • Medical Personnel
  • Molecules
  • Neoplasms
  • Oncology
  • Ovarian Cancer
  • Universities
  • Wisconsin

Readers

  • Clinical Trial Research.
  • Oncology
  • Research Science/Academic Research