Nanoencapsulation of OPAA With Mesoporous Materials for Chemical Agent Decontamination in Organic Solvents
Abstract
Organophosphorus acid anhydrolase (OPAA) offers great potential for safe, non-corrosive decontamination of a wide range of organophosphorus compounds, including the fluoride containing chemical nerve agent Soman and Sarin. The nanoencapsulation of OPAA with mesoporous materials provides a very stable and convenient formulation for use in chemical agent detoxification. In the present study, the enzyme was prepared in both hydrophilic and hydrophobic matrices and measured for activity against diisopropyl fluorophosphate using a F-specific electrode. The enzyme activity in different matrices was evaluated in various organic solvents. Significant activities were retained in most of these matrices, particularly in the presence of acetone and dimethyl formamide. These findings suggested that the OPAA- mesoporous hybrid materials might be suitable for a wide variety of applications including large area and personnel decontamination, individual protection, and detection.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2003
- Accession Number
- ADA483485
Entities
People
- H. Dong
- K. K. Ong
- Rui Yin
- T-c Cheng
- Yuting Wei
Organizations
- Drexel University