Effects of Indomethacin and Buprenorphine Analgesia on the Postoperative Recovery of Mice
Abstract
Buprenorphine (Bup) is the most commonly used analgesic in mice, yet few objective assessments address its superiority for postsurgical recovery. In mice, IP implantation of a radiotelemetry device induces decreases in body weight (BW), food and water intake (FI, WI), core temperature (Tc), and activity levels that persist approximately 14 d in the absence of analgesia. To compare the efficacy of (Bup with that of the nonsteroidal antiinflammatory drug indomethacin (Indo) for postsurgical recovery, male C57bl/6J mice were treated on the day of radiotelemetry implantation with (Bup (0.3 mg/kg SC) or Indo (1mg/kg SC) followed by treatment with Indo (1 mg/kg PO) on the next day ((Bup-Indo versus Indo-Indo_. Responses were compared between treatments in mice implanted with a radiotelemetry device and those that did not undergo surgery. Changes in BW, FI, WI, Tc, and activity were examined throughout 14 d of recovery. Indo-Indo was more efficacious in inhibiting postsurgical BW, FI, and WI reductions, compared with (Bup-Indo. (Bup also reduced BW and FI in the absence of surgery, indicating a nonspecific effect of this drug on these variables. Indo-Indo treatment was associated with higher activity levels during lights-on-to-lights- off transition periods compared with that observed with (Bup-Indo. According to 5 objective measures of surgical recovery, our data suggest that Indo-Indo treatment is more efficacious than is (Bup-Indo for postsurgical recovery of radiotelemetry-implanted mice.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2008
- Accession Number
- ADA483768
Entities
People
- L. R. Leon
- M. D. Blaha
Organizations
- United States Army Research Institute of Environmental Medicine