Inhalation Toxicity of Sarin (GB) Vapor in the Gottingen Minipig: Low-Level Threshold Effects
Abstract
The goal of these experiments was to determine the lowest sarin (GB) vapor concentration of physiological significance. Gottingen-minipigs were individually exposed to concentrations of GB vapor ranging from 0.03-2.0 mg/cu m for 60 minutes. Pupil constriction was assessed, under dim-light conditions, using an infrared light sensitive video camera and capturing high-resolution images of the eye before, during and after exposure. Pupil area was then quantified automatically off-line using a custom-designed software package. Pupil area was graphed as a function of time. The relationship between the dose-response curve (percent pupil constriction as a function of time) and vapor concentration was investigated.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2003
- Accession Number
- ADA483778
Entities
People
- B. J. Benton
- C. L. Crouse
- D. B. Miller
- D. R. Sommerville
- J. A. Scotto
- J. H. Manthei
- J. S. Forster
- K. L. Matson
- R. B. Crosier
- S. W. Hulet