Four-Week-Long Tabun Low-Level Exposure in Rats
Abstract
Prolonged administration of sublethal doses of organophosphorus cholinesterase inhibitors results in adaptation to their toxicity. In order to investigate this phenomenon, we exposed rats to 0.2, 0.3 or 0.4 LD50 of tabun sc daily during four weeks. AChE activities in erythrocytes, diaphragm and brain were inhibited dose-dependently after days 7 and 14 of the study and started to recover thereafter, except after 0.4 LD50. Tabun 0.3 LD50 decreased body weight gain, food and water consumption during the first two weeks of the study. Spontaneous locomotor activity was significantly increased in the same interval and decreased thereafter. These findings support the assumption that both the biochemical and receptor mechanisms are responsible for the occurrence of tolerance to tabun in rats.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2003
- Accession Number
- ADA483779
Entities
People
- Biljana Antonijevic
- Danka Stefanovic
- Dubravko Bokonjic
- Milos P. Stojiljkovic
- Vesna Kilibarda
- Zoran A. Milovanovic
Organizations
- Military Medical Academy