Photochemical Tissue Bonding for Military Medical Applications
Abstract
Report developed under STTR contract for topic number AF07-T033. The overall goal is to develop a complete system for micro-anastomosis of blood vessels. This involves (1) a unique laser system that uses water as the absorbing chromophore, (2) a clinically useful handpiece that is appropriate for microsurgery, (3) a novel albumin stent to support the vessel during anastomosis, (4) in vitro testing of the device to assess thermal damage, strength, and operative time. And (5) In Vivo animal testing will be added to Phase II. The goals of providing a 1.9um laser and an appropriate handpiece were accomplished in Phase I. Similarly the goals of manufacturing prototype albumin stents and applying them in vitro testing were met and proven effective by collection of pull test data to access joint strength, thermal damage studies and dissolution studies following application of the stents and laser "soldering" process to repair swine blood vessels. A Phase II program, if funded, is expected to lead to development of a commercially testable system for micro-anastomosis of blood vessels.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 30, 2008
- Accession Number
- ADA483796
Entities
People
- Dennis Mccal
- Scott Prahl