Generation, Sampling and Analysis for Low-Level GB (Sarin) Vapor for Inhalation Studies

Abstract

This study tested and optimized various methodologies to generate, sample and characterize GB test atmospheres in an inhalation chamber, particularly at low vapor levels. A syringe drive/spray atomization system produced GB vapor at lethal concentrations of 1- 44 mg/m3. A saturator cell was used to generate GB vapor at sub-lethal concentrations down to levels approaching the TLV-TWA of 0.0001 mg/m3. Both generation techniques demonstrated the ability to produce stable vapor concentrations over extended exposure periods for inhalation toxicology studies. The techniques employed for this study would lay the foundation for testing other chemical warfare agents, such as GF or VX.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2003
Accession Number
ADA483820

Entities

People

  • Charles L. Crouse
  • Kathy L. Matson
  • Sandra A. Thomson
  • William T. Muse Jr.

Organizations

  • Edgewood Chemical Biological Center

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Air
  • Analyzers
  • Atomization
  • Cells
  • Chemical Warfare
  • Chemical Warfare Agents
  • Demographic Cohorts
  • Detectors
  • Evaporation
  • Flow
  • Generators
  • Rodents
  • Sampling
  • Toxicity
  • Vaporization
  • Vapors

Readers

  • Aerosol Science/Aerosol Physics
  • Toxicology/Environmental Toxicology