Dietary Fat, Fat Metabolizing Genes and Prostate Cancer Risk in African-Americans and Whites
Abstract
Dietary fat has been implicated as a potential promotional factor leading to the progression of small, latent, nonmetastatic prostate tumors to invasive, metastatic lesions. One possible mechanism is conversion of the n-6 polyunsaturated fatty acids to inflammatory compounds produced by the lipoxygenase (LOX) family of enzymes. The authors are examining whether genetic variants in the n-6 fatty acid LOX pathways are associated with the risk of prostate cancer in a population-based case control study of advanced prostate cancer among African Americans and whites in Los Angeles County. In the first two years of the study, the authors genotyped five LOX gene polymorphisms, including 12-LOX Gln261Arg and Ser322Asn, 15-LOX-2 Gln656Arg, 5-LOX Lys254Glu, and the 5-LOX promoter Sp1 motif polymorphism. Preliminary analyses indicate that the 12-LOX gene Gln261Arg polymorphism may be related to prostate cancer risk in both African Americans and whites. In the third year, they will investigate whether genetic variation in specific LOX pathways, in combination with diet, contributes to prostate cancer risk. Their findings could provide a scientific foundation upon which to design dietary intervention trials and may allow them to design strategies for reducing the disparity in prostate cancer burden between African Americans and other ethnic groups.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 2005
- Accession Number
- ADA484212
Entities
People
- Sue A. Ingles
Organizations
- University of Southern California