Cells With Unique Properties in Prostate Cancer-Associated Storma Are Mesenchymal Stem Cells
Abstract
Our objective was to explore the hypothesis that prostate cancer-associated stromal cells are derived, at least in part, from mesenchymal stem cells. Our objective was to show that cancer-derived stromal cells capable of anchorage-independent growth have characteristics of stem cells and convert nontumorigenic prostatic epithelial cells to tumorigenicity. We could not identify cells capable of anchorage-independent growth, so we sought other stem cell markers. We pinpointed CD90 as a marker associated with mesenchymal stem cells that is overexpressed in cancer-derived stromal cells. In the no-cost extension period that we have requested, we will determine whether CD90-positive cells are capable of multilineage differentiation, and transforming nontumorigenic prostatic epithelial cells to tumorigenicity. Our studies also continue to point to high expression of transforming growth factor-beta as a key feature of prostate cancer-derived stromal cells that has also been to stem cell phenotypes.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2007
- Accession Number
- ADA484223
Entities
People
- Donna M. Peehl
Organizations
- Stanford University