Simultaneous Monitoring of Vascular Oxygenation and Tissue Oxygen Tension of Breast Tumors Under Hyperbaric Oxygen Exposure
Abstract
Objective/Hypothesis: By monitoring global and local vascular oxygenation and tissue oxygen tension in breast tumors under HBO exposure with several different gas interventions, we wish to prove the following two hypotheses: that 1) the combination of HBO and hyperoxic intervention can largely improve breast tumor oxygenation, and that 2) tumor oxygenation remains elevated for a period of time even after HBO exposure, which may provide a unique treatment window to enhance radiosensitivity. Specific Aims: Aim 1: to determine the absolute values of oxygenated hemoglobin concentration, [HbO2], and hemoglobin oxygen saturation, SO2, in solid breast tumors from the NIRS measurements. Aim 2: to investigate vascular oxygenation and tissue oxygen tension of breast tumors under continuous normobaric and hyperbaric oxygen exposures with several gas interventions, using both a single-channel NIRS system and 3-channel FOXY pO2 system simultaneously. Aim 3: to investigate global and local dynamics of tumor vascular [HbO2] and tissue pO2 of breast tumors immediately after HBO exposure using both three-channel NIRS and 19F MR EPI imaging simultaneously.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2007
- Accession Number
- ADA484242
Entities
People
- Hanli Liu
- Mengna Xia
Organizations
- University of Texas at Arlington