Molecular Mechanisms of Differential Effects of Calcitriol on Endothelial Cells Isolated from Prostate Tumor and Normal Microenvironment
Abstract
The focus of this project is to evaluate the effects of calcitriol (1,25-dihydroxycholecalciferol), the active form of vitamin D and/or dexamethasone on endothelial cells found in both tumor and non-tumor or normal microenvironments. Calcitriol has significant anti-tumor effects in LNCaP, PC-3, and MLL Dunning rat prostate models. Dexamethasone potentiates the antitumor effects of calcitriol. In mice, we have demonstrated that calcitriol s effect in vivo could contribute to its action on the endothelial cells (EC) found in the tumor (tumor-derived endothelial cells, TDEC). Preclinical data indicate that these effects were more profound in TDEC when compared to the endothelial cells isolated from matrigel plugs implanted in normal animals (matrigel-derived endothelial cells, MDEC). The differential effects observed could be due to differences in the availability of vitamin D receptor (VDR) to interact with the transcription machinery.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2006
- Accession Number
- ADA484270
Entities
People
- Ivy Chung
Organizations
- Health Research, Incorporated