Properties of Leukemia Stem Cells in a Novel Model of Cml Progression to Lymphoid Blast Crisis

Abstract

The objective of the study was to employ a novel mouse model of CML blast crisis to characterize various forms of leukemia stem cells (LSC) and their relative properties. In particular, distinguishing how differing normal target cells contribute to disease pathogenesis was regarded as an important priority in establishing relative heterogeneity of LSC.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2007
Accession Number
ADA484271

Entities

People

  • Craig T. Jordan

Organizations

  • University of Rochester

Tags

DTIC Thesaurus Topics

  • Anatomy
  • Antigens
  • Biological Sciences
  • Biomedical Research
  • Blood Cells
  • Cell Physiological Processes
  • Cells
  • Cells (Biology)
  • Contrast
  • Department Of Defense
  • Disease Attributes
  • Diseases And Disorders
  • Leukemia
  • Leukocytes
  • Pathogenesis
  • Sensitivity
  • Stem Cells

Readers

  • Marine Ecotoxicology
  • Molecular and Cellular Biology
  • Molecular and genetic basis of cancer.

Technology Areas

  • Biotechnology