Role of X-Linked Inhibitor of Apoptosis in Breast Cancer

Abstract

XIAP is an exciting potential target for breast cancer therapeutics but the specific functions of XIAP that contribute to breast cancer development or progression remain unknown. This project seeks to identify the properties of XIAP that play a crucial role in breast cancer using mutated XIAP molecules that are deficient in specific cellular functions in both in vitro and in vivo models of breast cancer. The tasks of the first phase of this project have been completed: establishing breast cancer cell lines deficient in XIAP or express only mutant forms of XIAP that can be used in models of anchorage-independent growth or tumor formation in immunocompromised mice. In the next phase of this project these cell lines will be evaluated to identify the role of XIAP in tumorigenesis which will be a valuable guide in the development of therapeutics that specifically target tumor-related functions of XIAP and in the advancement of our understanding of breast cancer biology.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2007
Accession Number
ADA484320

Entities

People

  • Karolyn Oetjen

Organizations

  • University of Michigan

Tags

DTIC Thesaurus Topics

  • Apoptosis
  • Biological Sciences
  • Biomedical Research
  • Breast Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Computer Programs
  • Culture Techniques
  • Inhibitors
  • Michigan
  • Molecules
  • Mutations
  • Neoplasms
  • Programmed Cell Death
  • Therapy
  • Universities

Fields of Study

  • Biology

Readers

  • Molecular Biology and Genetics