The Role of Smad4 on Tumorigenesis, ERK Pathway, and SERM Resistance in Estrogen Receptor Alpha-Positive Breast Carcinoma Cells

Abstract

This pre-doctoral training award was for Robert Nichols a Ph.D. graduate student to determine the interaction among signaling pathways of TGF-beta/Smad4 ERK and estrogen in the regulation of breast carcinogenesis and resistance to selective estrogen receptor modulators. During the past year the PI established various breast cancer cell lines with modulated expression of Smad4 and performed some proposed experiments using the established cell lines. However the progress was significantly hindered after the PI was ordered to join National Guard for combat training two months after the award and was eventually deployed in Iraq in May 2007. The mentor Dr. LuZhe Sun was asked by the DOD Program to prepare this interim progress report in lieu of an annual report.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2007
Accession Number
ADA484322

Entities

People

  • Robert Nichols

Organizations

  • University of Texas Health Science Center at San Antonio

Tags

DTIC Thesaurus Topics

  • Apoptosis
  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Department Of Defense
  • Diseases And Disorders
  • Estrogens
  • Hormone Antagonists
  • National Guard
  • Neoplasms
  • Peptide Growth Factors
  • Resistance
  • Training
  • Tumor Cell Line

Readers

  • Breast cancer cell signaling and growth regulation.
  • Clinical Trial Research.
  • Military Leadership and Professional Education.