Development of Immortalized Cell Lines from Hereditary Prostate Cancer Families

Abstract

Prostate cancer is a significant cause of morbidity and mortality in the United States. Several types of epidemiological studies confirm the existence of a genetic component to prostate cancer etiology. Hereditary prostate cancer (HPC) genes are predicted to account for about 43% of disease in men over 55, and 9% of total prostate cancer in men diagnosed through age 85. To best utilize the finite amount of DNA in blood samples previously collected from 271 HPC families, we are creating immortalized cell lines. The objective is to generate a long term resource of germline DNA from HPC families for use in mapping gene pathways associated with disease susceptibility.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2006
Accession Number
ADA484352

Entities

People

  • Elaine Ostrander
  • Janet Stanford

Organizations

  • Fred Hutchinson Cancer Center

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Cancer
  • Cell Line
  • Cells
  • Computational Biology
  • Data Sets
  • Department Of Defense
  • Diseases And Disorders
  • Electronic Mail
  • Families (Human)
  • Genetics
  • Mutations
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Systems Biology
  • United States

Fields of Study

  • Medicine

Readers

  • Infectious Disease/Epidemiology
  • Molecular Biology and Genetics
  • Oncology

Technology Areas

  • Biotechnology