Targeting the MTA 1s-LM04 Pathway in Hormone Resistance

Abstract

LIM domain transcriptional regulators are critical mediators of pattern formation, organogenesis and cell differentiation. The LIM-only proteins (LMO) consist nearly entirely of two LIM domains and utilize these cysteine-rich, zinc-coordinating regions to help dictate patterns of gene expression and cell fate through mediating protein-protein interactions with DNA binding proteins and transcriptional coregulators. In addition to their developmental roles, LMO proteins may also be critical mediators of cancer development.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Mar 01, 2006
Accession Number
ADA484467

Entities

People

  • Christopher J. Barnes

Organizations

  • The University of Texas MD Anderson Cancer Center

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Carrier Proteins
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Confocal Microscopy
  • Gene Expression
  • Hormones
  • Molecular Biology
  • Neoplasms
  • Protein-Protein Interactions
  • Proteins
  • Resistance
  • Targeting

Readers

  • Molecular Biology and Genetics