Targeted Eradication of Prostate Cancer Mediated by Engineered Mesenchymal Stem Cell

Abstract

Prostate cancer metastases, especially bone metastases, are the major reason account for high mortality of advanced prostate cancer as they can not be reached by any currently used regimens without detrimental side effects to the patients. Even though the exact mechanism of preferential prostate cancer bone metastasis has not yet been well understood, it is speculated that the migration and establishment of these cancer cells in the bone compartment is contributed by the stimulatory and supportive roles of bone marrow stroma cells or mesenchymal stem cells (MSC). We thus hypothesize that targeting the tumor supportive stroma cells via MSC would represent one promising avenue for our long-term goal of developing an innovative non-invasive approach for treating metastatic prostate cancers.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2007
Accession Number
ADA484564

Entities

People

  • Yan Cui

Organizations

  • Louisiana State University

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Blood Coagulation Factors
  • Body Weight
  • Bone Marrow
  • Cancer
  • Cell Line
  • Cells
  • Culture Techniques
  • Endothelial Cells
  • Environment
  • Gene Therapy
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Stem Cells
  • Therapy
  • Universities

Readers

  • Oncology (Cancer Research).

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech