MicroRNAs in Prostate Cancer

Abstract

In the first year of this project we have cloned microRNAs from two prostate cancer cell lines, PC3 and LnCAP, the latter from cells grown in the absence and presence of androgens. The clones have been subjected to sequencing and the sequences are being deconvoluted to identify the cloned microRNAs. We have also prepared microRNAs from LnCAP cells plus and minus androgens and established conditions to hybridize them to microarrays of microRNAs in an attempt to determine which microRNAs are up- or down-regulated by androgen treatment.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 2006
Accession Number
ADA484629

Entities

People

  • Anindya Dutta

Organizations

  • University of Virginia

Tags

DTIC Thesaurus Topics

  • Anatomy
  • Androgens
  • Biological Sciences
  • Biomedical Research
  • Cell Line
  • Cells
  • Department Of Defense
  • Electronic Mail
  • Gene Expression
  • Genes
  • Genetics
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Sequences
  • Tumor Cell Line
  • Virginia

Fields of Study

  • Biology

Readers

  • Molecular Genetics
  • Prostate Cancer Biology.