Role of cdc25 Phosphatases in Human Breast Cancer
Abstract
A summary is presented of research performed during the second year of a project to determine the role of Cdc25 phosphatases in human breast cancer. The research involves three specific aims. In the first aim, the role of Cdc25B in breast cancer proliferation will be determined. Examining whether alternative splicing of Cdc25C contributes to human breast cancer is the focus of the second aim. Finally, a potential novel breast cancer therapy involving altered expression of Cdc25C will be explored. The long term goals of this research are to validate a clear role for Cdc25B in breast tumor cell proliferation and to rigorously determine whether Cdc25C may contribute to human breast tumorigenesis in other ways besides its overexpression.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2007
- Accession Number
- ADA484675
Entities
People
- James J. Manfredi
Organizations
- Icahn School of Medicine at Mount Sinai