Topical Application of Liposomal Antioxidants for Protection Against CEES Induced Skin Damage

Abstract

This study was successful in developing an effective prophylactic therapy against skin damage caused by an analog of mustard gas, 2-chloroethylethyl sulfide (CEES) using in vitro model systems. The therapy is based on the topical application of antioxidant liposomes. Both EpiDerm cultured human skin tissues as well as cultured keratinocytes were used as the in vitro model systems. Our results show that CEES pathophysiology involves oxidative stress and liposomes containing both water- and lipid-soluble antioxidants are, therefore, likely to be effective therapeutic agents for protecting US military and civilians from a chemical warfare agent such as mustard gas (HD). In summary, we have determined the therapeutic efficacy as well as the chemical and physical stability of various antioxidant liposome formulations for future testing in animal models.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2008
Accession Number
ADA484705

Entities

People

  • Hongsong Yang
  • Victor Paromov
  • William L. Stone

Organizations

  • East Tennessee State University

Tags

DTIC Thesaurus Topics

  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Health Services
  • Medical Personnel
  • Organic Chemistry
  • Proteins

Readers

  • Geochemistry
  • Oncology (Cancer Research).
  • Toxicology/Environmental Toxicology