Modeling Phenotypes of Tuberous Sclerosis in the Mouse
Abstract
The overall goal of this project is to generate a mouse model of the smooth muscle-related facets of tuberous sclerosis specifically in an attempt to model the lung phenotype seen in a subset of TS patients and patients with LAM. We have conditionally targeted the TSC1 gene in smooth muscle which results in mortality at approximately 10 weeks of age. This mouse now provides a useful model in which to investigate the function of individual MMPs or other proteins in this pathological progression and to evaluate relevant therapeutic interventions such as rapamycin.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 2006
- Accession Number
- ADA484804
Entities
People
- James M. Shipley
Organizations
- Washington University in St. Louis