Searching the Epigenome for Novel Breast Cancer Tumor Suppressors
Abstract
Our initial proposal focused on developing technologies to uncover epigenetic changes that contribute to tumor development. Our initial attempts towards developing genome wide approaches to identify new genes silenced by epigenetic mechanisms encountered problems; however, our efforts to exploit epigenetic mechanisms of gene silencing to study tumor suppressor gene function have been very successful. Therefore, as we enter the second year of funding we plan to capitalize on the success of the latter experiments to refocus our effort. Our new objectives will build upon the unanticipated advances that we have made in the use of RNAi to manipulate gene expression in mouse and human cell systems and in animal models to explore the role of epigenetic modifications in breast cancer progression.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2004
- Accession Number
- ADA484851
Entities
People
- Gregory Hannon
Organizations
- Cold Spring Harbor Laboratory