Role of CYP1B1 in PAH-DNA Adduct Formation and Breast Cancer Risk

Abstract

Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous in the environment from incomplete combustion of fossil fuels and other industrial sources. The genotoxic impact of PAHs depends on their metabolism to more reactive intermediates. The major pathway by which ingested or inhaled PAHs are metabolized, is the stepwise oxidative activation by the cytochrome P450 isozymes, CYP1A1 and CYP1B1, followed by detoxification by phase II enzymes (Nebert and Gonzales, 1987).

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2008
Accession Number
ADA485317

Entities

People

  • Regine Goth-goldstein

Organizations

  • University of California, Berkeley

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Aromatic Hydrocarbons
  • Biomedical Research
  • Breast Cancer
  • Cyclic Hydrocarbons
  • Department Of Defense
  • Electronic Mail
  • Fossil Fuels
  • Hydrocarbon Fuels
  • Hydrocarbons
  • Information Operations
  • Maryland
  • Neoplasms

Fields of Study

  • Environmental science

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