The Modulation of Fibrosis in Scleroderma by 3-Deoxyglucosone
Abstract
Scleroderma is a disease where excess collagen is deposited in the skin and internal organs. The tissues become hard and in the end fail to function. To date there is no cure nor is there an effective therapy that will control the deposition of the collagen. The goals of this application were to investigate the cellular signaling within fibroblasts that were mediated by the glycation end product 3DG. We find that 3DG decreases the expression of collagens and therefore we proposed to understand the cellular signaling in fibroblasts in response to this compound. We have found that 3DG induced caspase 3 expression an apoptotic gene and decreased cell proliferation. We also have found that there are alterations in the expression of the integrins on the fibroblast cell surface with increased expression of integrins alpha2, alpha5, and alphav; and decreased expression of Beta3. Integrins interface between the extracellular matrix and the cell transmitting signals into the nucleus. Alterations in the expression of the integrins will change the signaling within the fibroblast. This signaling we are still unraveling.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 2008
- Accession Number
- ADA485330
Entities
People
- Carol M. Artlett
Organizations
- Drexel University