Identification of Ovarian Cancer Susceptibility Genes Involved in Stromal-Epithlial Interactions

Abstract

The purpose of this project is to identify ovarian cancer susceptibility genes involved in stromal-epithelial cross talk. We have now genotyped 2138 samples for 1536 tagging, non-synonymous and miRNA binding site SNPs in 174 genes. Following Quality Control exclusions, the final dataset comprised 1839 samples (675 cases and 1164 controls) with genotype information for 1292 SNPs in 174 genes. We are using P(trend) values to select 25-30 SNPs for independent validation in ~2000 cases and ~4000 controls from other sites. Four of these SNPs will also be genotyped by the whole of the Ovarian Cancer Association Consortium (OCAC) (~4500 case and ~6500 controls). Currently our most significant finding is for a SNP in the podocalyxin-like (PODXL) gene for which the P(trend) = 0.0001, with a Positive Predictive Value of 33 %, and a Homozygote OR = 1.75 (95% CI 1.28-3.38).

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 2008
Accession Number
ADA485331

Entities

People

  • Alice Whittemore
  • David Duffy
  • Dorota Gertig
  • Ellen L Goode
  • Georgia Chenevix-Trench
  • Hoda Anton-Culver
  • Izhak Haviv
  • Joellen Schildkraut
  • Leigh Pearce
  • Paul D P Pharoah
  • Penelope M. Webb

Organizations

  • QIMR Berghofer Medical Research Institute

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Cancer
  • Cells
  • Consortiums
  • Culture Techniques
  • Data Sets
  • Genes
  • Genetic Phenomena
  • Genetics
  • Genotypes
  • Neoplasms
  • Ovarian Cancer
  • Prostate Cancer
  • Quality Control
  • Statistical Analysis
  • Test Sets
  • Validation

Fields of Study

  • Biology

Readers

  • Molecular and genetic basis of cancer.