Structure Optimization of 21,23-Core-Modified Porphyrins Absorbing Long-Wavelength Light as Potential Photosensitizers Against Breast Cancer Cells
Abstract
In the first year, we made eighteen new 21,23-core modified porphyrins, determined their photophysical properties, and evaluated the biological properties of them. In the second year, the research focused on 1) analyzing quantitative structure-activity relationships (QSAR) of the porphyrins prepared in the first year, 2) establishing new synthetic methods for novel structures and preparing them. In the third year, the structures of two derivatives were determined unambiguously be x-ray crystallography. A series of carboxylic acid-substituted dithiaporphyrins was prepared with different length aliphatic spacers between porphyrin and acid. The efficiency of them was studied and mode of binding with lipid model was studied. In addition, we made novel structures having different core and meso substitution patterns and tested them with in vitro model.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2008
- Accession Number
- ADA485339
Entities
People
- Michael R. Detty
Organizations
- State University of New York at Albany