Radiation Sensitization via Inhibiting Survival of Prostate Cancer and Its Vascular Endothelium

Abstract

This research focuses on tissue analyses and novel agents for prostate cancer. The authors have collected cancer tissue samples from close to 1,000 cases of prostate cancer. DNA samples were extracted from 250 cases. Genotyping of various single nucleotide polymorphisms (SNPs) revealed that a SNP from EGFR and another SNP from MMP7 were significantly associated with prostate cancer recurrence, by univariate or multivariate analyses. Ongoing experiments spurred by these findings aim to determine whether the the therapeutic efficacy of radiotherapy and chemotherapy in prostate cancer models. They also investigate small molecule compounds such as aurora kinase inhibitors in radiosensitizing prostate cancer models.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 2008
Accession Number
ADA485350

Entities

People

  • Bo Lu

Organizations

  • Vanderbilt University Medical Center

Tags

DTIC Thesaurus Topics

  • Cancer
  • Cell Physiological Processes
  • Diseases And Disorders
  • Health Services
  • Inhibitors
  • Institutional Review Board
  • Lung Cancer
  • Medical Personnel
  • Neoplasms
  • Oncology
  • Prostate Cancer
  • Radiation
  • Radiotherapy
  • Small Molecules
  • Survival
  • Therapy
  • Tissues

Fields of Study

  • Biology
  • Medicine

Readers

  • Molecular and genetic basis of cancer.
  • Oncology (Cancer Research).
  • Regression Analysis.