Intra-Operative Dosimetry in Prostate Brachytherapy
Abstract
Favorable outcome in prostate brachytherapy critically depends on the accurate placement of radioactive sources in their planned locations. Unfortunately, there is variety of mechanical factors that cause the seeds to divert from their planned locations. While this problem has been known to brachytherapists, current technology does not allow for reliable localization of the implanted sources, thereby prohibiting the prediction and modification of seed distribution intra-operatively. The Research Objective of the proposal is to develop and evaluate ex-vivo a method for intra-operative localization of the implanted seeds in relation to the prostate, to facilitate in-situ dosimetric optimization and exit dosimetry. In particular, we will: [1] Registration of Ultrasound to Fluoroscopy (RUF): Develop methods for reconstruction of seed implants from X-ray fluoroscopy and spatially register them to the prostate anatomy identified in TRUS [2] System Integration: Integrate the above methods in a software package and link it with the FDA-approved CMS Interplant prostate brachytherapy system to enable in-situ dosimetry calculation [3] Experimental Validation: Evaluate the performance of the RUF system on phantoms and pre-recorded patient data.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2008
- Accession Number
- ADA485393
Entities
People
- Ameet Jain
Organizations
- Johns Hopkins University