Non-Invasive Nanodiagnostics of Cancer (NINOC)

Abstract

This project seeks to develop noninvasive diagnostics to detect cancer in its earliest, most easily treatable, pre-symptomatic stage. Innovative imaging nanomaterials and delivery technologies is employed to target, label and detect the cancer cells within the body at sites which are normally inaccessible to conventional diagnostic methods. The hydrophilic polymer nanogels of core-shell morphology are designed to entrap different types of probes used in single photon emission computed tomography, computer tomography, magnetic resonance or luminescence detection. The surface of the nanogels is modified with genetically engineered antibody fragments to target the surface of cancer cells and provide site-specific delivery of the nanogels to tumors in the body.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2008
Accession Number
ADA485522

Entities

People

  • Alexander Kabanov

Organizations

  • University of Nebraska Medical Center

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Block Copolymers
  • Chemical Engineering
  • Chemical Synthesis
  • Chemistry
  • Detection
  • Detectors
  • Health Services
  • Hydrophilic Properties
  • Hydrophobic Properties
  • Macromolecules
  • Magnetic Resonance
  • Molecules
  • Nanomaterials
  • Organic Chemistry
  • Polymers
  • Proteins
  • X-Ray Computed Tomography

Fields of Study

  • Physics

Readers

  • Medical Imaging.
  • Nanocomposite Materials Science

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech