Characterize RAP80, a Potential Tumor Suppressor Gene
Abstract
To examine the molecular mechanism by which BRCA1 participates in breast tumor suppression we have identified that RAP8O is a BRCA1-associated protein by protein affinity purification. Here we show the evidence that RAP8O controls BRCA1's relocation to DNA damage sites and regulates BRCA1-dependent DNA damage checkpoint function. In addition we have identified a truncation mutation of RAP8O in an ovarian cancer cell line. Thus our results indicate that RAP8O is a functional partner of BRCA1 and may participate in breast tumor suppression. These results has been published in Science (vol. 3161202-1205) and Nature Structural and Molecular Biology (Vol. 14 716-720).
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2008
- Accession Number
- ADA485703
Entities
People
- Xiaochun Yu
Organizations
- University of Michigan