Understanding the Mechanism through which Matrix Metalloproteinases (Mmps) Contribute to Breast Cancer-Associated Osteolytic Lesions
Abstract
Bone metastasis is a common event during breast cancer (BC) progression. Matrix Metalloproteinases (MMPs) are often overexpressed in BC and play an important role in tumor progression. Metastatic BC is typically osteolytic and we hypothesize that specific stromal and tumor MMPs contribute to the growth and development of osteolytic lesions. To address the role of individual stromal MMPs in vivo we used an intratibial model that recapitulates breast induced osteolysis. We demonstrated that stromal MMP-2 and MMP-7 are required for mammary tumor growth in the bone and the development of osteolytic lesions. However MMP-9 does not affect tumor growth and bone resorption in our model of mammary tumor-associated bone lesions. These findings emphasize the need to delineate the role of specific MMPs in breast induced-bone osteolysis to hopefully open the way for new therapeutics.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 2008
- Accession Number
- ADA485994
Entities
People
- Sophie Thiolloy
Organizations
- Vanderbilt University Medical Center