Promotion of Epithelial to Mesenchymal Transformation by Hyaluronan

Abstract

The homeostasis observed in an organ is a consequence of a coordinated multidirectional communication between the epithelium and its microenvironment through physical and biochemical signals. An interruption of this communication can lead to the formation of cancer. One of the major components of mammary gland microenvironment, also called stroma, is hyaluronan (HA). It has been proposed that HA may induce malignant transformation in normal cells through interaction with its receptors. However, HA's function during normal mammary gland development is still unknown and we therefore wanted to elucidate its function during normal development before taking a closer look at its possible functions during breast cancer.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 2007
Accession Number
ADA486130

Entities

People

  • Silva Krause

Organizations

  • Tufts University

Tags

DTIC Thesaurus Topics

  • Breast Cancer
  • Cell Membrane Structures
  • Cell Physiological Processes
  • Cells
  • Culture Techniques
  • Developmental Biology
  • Electronic Mail
  • Epithelial Cells
  • Epithelium
  • Intercellular Junctions
  • Mammary Glands
  • Medical Personnel
  • Microscopy
  • Neoplasms
  • Three Dimensional
  • Tissues
  • Two Dimensional

Readers

  • Molecular Biology and Genetics
  • Systems Analysis and Design