The Role of ABC Proteins in Drug Resistant Breast Cancer Cells

Abstract

This predoctoral training grant, supported by the Department of Defense Breast Cancer Research Program (BCRP) of the Office of the Congressionally Directed Medical Research Programs (CDMRP), aims to study the possible role of ABC transporters in pleitropic drug resistance, using a combination of molecular biological, biochemical, and biophysical methods. The second year of funding was spent working with a member of a drug/metabolite transporter superfamily called the Plasmodium falciparum Chloroquine Transporter (PfCRT). While PfCRT is known to be the main molecular determinant of chloroquine resistance, there is only indirect proof of its interaction with the drug. Therefore, I have employed a methodology commonly applied to drug resistance proteins (such as human P-glycoprotein) and labeled PfCRT with a photoaffinity drug analogue. A manuscript is currently in preparation detailing my results.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2008
Accession Number
ADA486167

Entities

People

  • Jacqueline K. Lekostaj

Organizations

  • Georgetown University

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Biochemistry
  • Biomedical Research
  • Breast Cancer
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Department Of Defense
  • Drug Resistance
  • Fungi
  • Infectious Diseases
  • Malaria
  • Molecules
  • Neoplasms
  • Organic Chemistry
  • Proteins

Fields of Study

  • Biology
  • Chemistry
  • Medicine

Readers

  • Molecular and Cellular Biochemistry
  • Oncology (Cancer Research).
  • Parasitology and Pharmacology of Malaria.

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech