Immunology, Systems Biology, and Immunotherapy of Breast Cancer
Abstract
In year 2, we made substantial progress in multiple areas. We have an efficient system in place to recruit patients into this study and procure their samples. However, limited numbers of subjects available and limited amounts of clinical materials available from each subject remain major challenges to the success of this project-we continually attempt to address and solve this issue. We have developed a powerful set of immunological assays and molecular tools to study these samples in greater detail than previously possible. We are constantly striving to minimize the numbers of cells we need to generate useful data, and have to make decisions to pursue only the most promising assays with many samples. We are beginning to uncover dramatic changes in the immune cell populations within tumors, TDLNs, and peripheral blood from breast cancer patients. These will provide important insights into how breast cancer alters the host immune system. We look forward in the coming year to build upon the early data we are generating to come up with meaningful observations and insights into the immunobiology of breast cancer. In the coming year and beyond, we will also begin to make progress on the systems biology that will ultimately position us for the immunotherapy of breast cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 2008
- Accession Number
- ADA486170
Entities
People
- Peter P Lee
Organizations
- Stanford University