The Role of ADAM9 in Tumor-Stromal Interactions in Breast Cancer
Abstract
The tasks outlined in the Statement of Work for the second year of research on the action of ADAM9 isoforms in tumor-stromal interactions focused on the role of endogenous ADAM9 in breast cancer cell migration, and the elucidation of which major function of the protein is mechanistically relevant to cell migration. The major developments during this research period were the creation of an shRNA model system to evaluate the silencing of endogenous ADAM9 isoforms in breast cancer cell lines, and the reconstitution of gene expression with wild-type or functional mutants of both ADAM9 isforms to evaluate the distinct roles the functions of ADAM9 play in mediating cell migration.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2008
- Accession Number
- ADA486213
Entities
People
- Jessica L. Fry
Organizations
- Beth Israel Deaconess Medical Center