Targeted Therapies for Myeloma and Metastatic Bone Cancers

Abstract

Developed methods to radiolabel polymer nanoparticles, the first time to our knowledge this has been done. Quantified functional groups available for ligand conjugation using S35-labeled ligands. Developed alternative assay to confirm affinity of bone-targeting nanoparticles to hydroxyapatite substrates. Demonstrated in vitro stability of radiolabeled nanoparticles. Successfully transferred our nanoparticle preparation protocols to another facility to support in vivo biodistribution studies. Started in vivo biodistributions validating ability of our radiolabeled nanoparticles to be imaged for up to 48 hours and further confirming our protocol methods to study bone-targeting nanoparticle biodistribution via radio-imaging.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 2008
Accession Number
ADA486227

Entities

People

  • Neal Vail

Organizations

  • Southwest Research Institute

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Biomedical Research
  • Bone And Bones
  • Bone Cancer
  • Chemical Synthesis
  • Chemistry
  • Diseases And Disorders
  • Encapsulation
  • Materials
  • Materials Science
  • Nanoparticles
  • Neoplasms
  • Particle Size
  • Particles
  • Polymers
  • Substrates
  • Targeting

Fields of Study

  • Medicine

Readers

  • Medical Imaging.
  • Nanocomposite Materials Science
  • Oncology (Cancer Research).

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech