Pharmacological Studies of NOP Receptor Agonists as Novel Analgesics

Abstract

These experiments demonstrated that (1) intrathecal N/OFQ did not produced hyperalgesia-like effects as reported in rodents, (2) systemic Ro 64-6198 produced antinociceptive effects that are independent from mu opioid receptors, and (3) activation of NOP receptors produced antinociception without reinforcing/abuse liability in monkeys. Ro 64-6198 has only been studied in rodent species. This is the first functional study to investigate the behavioral effects of Ro 64-6198 in primates. More importantly, Ro 64-6198 produces antinociception like alfentanil, a commonly used mu opioid analgesic in the clinic, in two primate nociceptive models, but Ro 64-6198 does not produce reinforcing effects /abuse liability like mu receptor opioid analgesics. These findings may indicate that NOP receptor agonists may be a new generation of novel analgesics without abuse liability.

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Document Details

Document Type
Technical Report
Publication Date
May 01, 2008
Accession Number
ADA486620

Entities

People

  • Mei-Chuan Ko

Organizations

  • University of Michigan

Tags

DTIC Thesaurus Topics

  • Analgesics
  • Biomedical Research
  • Central Nervous System Depressants
  • Confidence Limits
  • Department Of Defense
  • Drug Abuse
  • Electronic Mail
  • Information Operations
  • Ketamine
  • Medical Personnel
  • Narcotics
  • Nerve Fibers
  • Opioids
  • Pain
  • Pain Management
  • Social Sciences
  • Spinal Cord

Fields of Study

  • Biology

Readers

  • Neurotrauma and Rehabilitation Medicine.
  • Underwater engineering and Marine Technology.
  • Virology (or Medical Virology).