Do Carcinoma-Associated Fibroblasts Adjacent to Breast Cancer Cells Originate from Circulating Mesenchymal Stem Cells?
Abstract
An understanding of the factors outside the cancer cell that promote invasion and metastasis or keep the cell contained could provide an entirely new avenue of therapy that tumour cells may find difficult to evade, and could prove relevant to patients who are resistant to current therapy. The overall aim of this proposal is to determine whether cancer associated fibroblasts (CAFs), which promote tumor progression, arise locally in the tumour bearing tissue or whether they are recruited from other organs such as bone, bone marrow or other precursor pools. Aims: 1) To determine whether bone marrow derived fibroblast precursor cells migrate to the site of primary tumors and become CAF; 2) To isolate bone marrow derived fibroblast precursors from primary tumors and test their ability to promote tumor growth and distant metastasis.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2007
- Accession Number
- ADA486641
Entities
People
- Izhak Haviv
Organizations
- University of Melbourne