Identification of Genes Regulating the Development of Breast Cancer
Abstract
We have identified four different modifiers of Apc(min) that affect mammary tumor number or mammary tumor latency (Mmom1-Mmom4). To further investigate the molecular mechanisms of mammary modifiers, Mmom1 and Mmmom2 congenic mice were produced and tested for the effect on mammary tumor number or mammary tumor latency. The effect of Mmom2 on mammary tumor latency was confirmed in the congenic mice and the region containing Mmom2 was narrowed into a 10cM region. We also show in this report that genetic background can determine the mammary tumor types in Apc(min) mice and we propose a model to explain how mammary modifiers could affect mammary tumor development.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 2008
- Accession Number
- ADA486671
Entities
People
- Hua Wang
Organizations
- University of Wisconsin–Madison