Estrogen Metabolism and Prostate Cancer Risk: A Prospective Study
Abstract
Prostate cancer is the most common cancer among men in the United States (IARC, 1995) and the second most common in the European Community (IARC, 1995). The causes of prostate cancer, however, remain largely unknown, with age, race, and family history being the only established risk factors (Nomura et al., 1997). The prostate gland has historically been considered the prototype of an androgen-dependent organ. However, there is evidence that estrogens may induce mitosis of prostatic epithelial cells in many species, including humans (Leave et al., 1978; Schulze et al., 1987). This report analyzes the association between prostate cancer and estrogen metabolism investigated in a case-control study. In particular, we tested the hypothesis that the pathway favoring 2-hydroxylation over 16alpha-hydroxylation may be associated with a decrease in prostate cancer risk. This is the final report for the study. During the final year of activity, we completed determinations of the estrogen metabolites using gas-chromatography and carried out statistical analysis.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2007
- Accession Number
- ADA487437
Entities
People
- Paola Muti