Studies on Axonal Transport in an Animal Model for Gulf War Syndrome
Abstract
Gulf War Veterans are more prone to neurodegeneration, presumably due to a combination of toxins to which they were exposed together with stress. The hypothesis of the project was that these toxins might adversely affect the transport of subcellular elements called microtubules within the nerves, and that potential therapies could be developed accordingly. The one year of work did not resolve the issue, but progress was made toward refining the best experimental paradigm in which to test the hypothesis, and progress was made toward refining therapies based on novel tools that target a microtubule-based motor protein called kinesin-5 and microtubule-severing proteins called katanin and spastin.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2008
- Accession Number
- ADA487439
Entities
People
- Peter W Baas
Organizations
- Drexel University College of Medicine