CXCL5 is a Novel Mediator of Prostate Cancer Proliferation and Migration/Invasion

Abstract

The primary concept driving this proposal is that CXCL5 may provide a link between aging and the development of malignant proliferative prostatic disease, and may act as a previously unrecognized growth factor that promotes prostate cancer cell proliferation and migration/invasion. The major findings of these studies are that CXCL5 protein expression levels are significantly elevated in primary and metastatic prostate tumors, that CXCL5 induces prostate cancer cell proliferation, migration and invasion in vitro, and that CXCL5 activates both MAPK and PI3K signaling and stimulates gene transcription in both nontransformed and transformed prostate epithelial cells. These findings suggest that CXCL5 works at many levels to promote prostate tumor progression and metastasis. Moreover, CXCL5 may provide a non-steroidal therapeutic target useful towards the treatment of hormone refractory prostate cancers.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2008
Accession Number
ADA488016

Entities

People

  • Jill Macoska

Organizations

  • University of Michigan

Tags

DTIC Thesaurus Topics

  • Apoptosis
  • Blood
  • Cancer
  • Carcinoma
  • Cell Physiological Processes
  • Cells
  • Culture Media
  • Diseases And Disorders
  • Epithelial Cells
  • Growth Factors
  • Metastasis
  • Neoplasms
  • Polymerase Chain Reaction
  • Prostate Cancer
  • Proteins
  • Statistical Analysis
  • Tissues

Fields of Study

  • Medicine

Readers

  • Breast cancer cell signaling and growth regulation.
  • Oncology (Cancer Research).