ER/PR Status of the Originating Cell of ER-Negative Breast Cancer

Abstract

The goal of this study is to test whether ER breast cancers arise from ER or ER+ mammary cells. We specifically hypothesize that ER is absent in the originating cell of ER-negative breast cancer. Although until now it has been technically difficult to test it, we have developed a unique mouse model based on the RCASTVA technology that allows us to trace the ER status of the cancer-originating cell. It is now possible to test this hypothesis in experimental mice.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 2008
Accession Number
ADA488026

Entities

People

  • Yi Li

Organizations

  • Baylor College of Medicine

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Biomolecules
  • Breast Cancer
  • Cancer
  • Cell Lineage
  • Cells
  • Chemical Compounds
  • Cultured Cells
  • Department Of Defense
  • Diseases And Disorders
  • Epithelial Cells
  • Estrogens
  • Glands
  • Growth Factors
  • Information Operations
  • Mammary Glands
  • Neoplasms

Readers

  • Breast cancer cell signaling and growth regulation.
  • Oncology and Biomarker-Based Cancer Detection.
  • Systems Analysis and Design