Crosstalk Between Cancer Cells and Bones Via the Hedgehog Pathway Determines Bone Metastasis of Breast Cancer

Abstract

The Hh pathway has been extensively studied in development and recently has also been shown to be activated in a variety of cancer types thus making it a putative therapeutic target. Our preliminary data indicated that OPN is a transcriptional target of Gli1 = Gli1 is a transcription factor of the Hedgehog (Hh) pathway. Research in our laboratory indicates that OPN is under direct control of the Hh pathway as seen by the effect of agonistic Hh pathway ligands and the Hh pathway inhibitor cyclopamine. Moreover we find that the Hh ligands Shh and lhh can stimulate differentiation of osteoblasts. The OPN-containing conditioned medium from the MDA-MB-435 cells is also able to potentiate differentiation of osteoblasts.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2008
Accession Number
ADA488055

Entities

People

  • Lalita Shevde-samant

Organizations

  • University of South Alabama

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Blood
  • Bones
  • Breast Cancer
  • Cancer
  • Cell Line
  • Cells
  • Co-Channel Interference
  • Inhibitors
  • Macrophages
  • Metastasis
  • Molecules
  • Neoplasms
  • Osteoblasts
  • Research Facilities
  • Targets
  • Transcription Factors

Fields of Study

  • Biology
  • Chemistry

Readers

  • Oncology (Cancer Research).
  • Prostate Cancer Biology.