A Role for Ubiquitin Binding in Bcr-Abl Transformation

Abstract

We have previously identified a docking site for ubiquitin in the amino-terminus of p210 BCR/ABL. Since ubiquitin binding has been implicated in both the intra- and inter-molecular regulation of many signaling molecules this association may have important clinical consequences for chronic myelogenous leukemia. During Year 1 of this study, we have precisely mapped the binding site for ubiquitin and generated a p210 BCR/ABL mutant that is completely impaired in binding in mammalian cells. Loss of ubiquitin binding does not destabilize p210 BCR/ABL thus allowing us to directly evaluate the mutant in assays for leukemogenic activity. This mutant will provide us with a unique opportunity to directly assess the importance of the ubiquitin-p210 BCR/ABL interaction in CML. These studies will be performed in Year 2 of this study.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2008
Accession Number
ADA488129

Entities

People

  • Ian P. Whitehead

Organizations

  • University of Medicine and Dentistry of New Jersey

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Amino Acids Peptides And Proteins
  • Biological Processes
  • Biomedical Research
  • Biomolecules
  • Biopolymers
  • Carrier Proteins
  • Cells
  • Chemical Compounds
  • Leukemia
  • Macromolecules
  • Molecules
  • New Jersey
  • Polymers
  • Proteins
  • Regulations
  • Structural Integrity

Fields of Study

  • Biology
  • Medicine

Readers

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