Role of cdc25 Phosphatases in Human Breast Cancer
Abstract
A summary is presented of research performed during three years of a project to determine the role of Cdc25 phosphatases in human breast cancer. Three specific aims were pursued. The first was to determine the role of Cdc25B in breast cancer proliferation. The second aim was examining whether alternative splicing of Cdc25C contributes to human breast cancer. The final aim was to explore a potential novel breast cancer therapy involving altered expression of Cdc25C. The long term goals of this research were to validate a clear role for Cdc25B in breast tumor cell proliferation and to rigorously determine whether Cdc25C may contribute to human breast tumorigenesis in other ways besides its overexpression.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2008
- Accession Number
- ADA489010
Entities
People
- James J. Manfredi
Organizations
- Icahn School of Medicine at Mount Sinai