Replicating Physiological Patterns of Activity with Prosthetic Stimulation
Abstract
We want to develop more effective methods of neural stimulation in order to improve the clinical outcomes associated with retinal prosthetics. To accomplish this we are investigating the mechanism(s) by which different types of retinal neurons respond to electric stimulation. Previous studies have shown that ganglion cells the output cells of the retina can be activated directly and exclusively with short duration stimulus pulses [1; 12; 24; 42]. However the site of spike initiation in ganglion cells (e.g. the element with the lowest threshold) is not known. Here we found that the lowest thresholds occurred along the proximal axon about 40 <m from the soma; this region of low threshold was spatially coextensive with a band of dense sodium channels also centered about 40 <m from the soma. The sodium channel bands formed a homogeneous population for a given type of ganglion cell (e.g. alpha) but the properties of the band were different across different types (e.g. the lengths and locations varied). As expected from the differences in band properties the size and location of the low threshold regions were also different for different ganglion cell types. We also showed that axonal thresholds can be quite low - in some cases lower than those found in the proximal axon region. This raises the possibility that a small stimulating electrode can elicit widespread neural activity. We continue to explore the mechanism underlying axonal activation with the hope of learning how to limit activation to the region around the somaiproximal axon.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2008
- Accession Number
- ADA489407
Entities
People
- Shelley Fried
Organizations
- Boston VA Research Institute