In Silico Genome Mismatch Scanning to Map Breast Cancer Genes in Extended Pedigrees
Abstract
This project aims to map breast cancer genes using dense single nucleotide polymorphism arrays in large extended pedigrees. Data has been collected using a 1,000,000 SNP genotype assay for 25 women affected by breast cancer in three high risk Utah pedigrees. Preliminary analysis of control data has been performed and significant progress has been made on the problem of modeling linkage disequilibrium between genetic loci at the density and scale required by this project. Programs to perform the modeling and analysis have been written and tested. Two papers describing the methodological developments have been published and a third describing initial analyses of control data is in preparation. The project is proceeding as planned and we expect to carry out the remainder in good time.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 2008
- Accession Number
- ADA489763
Entities
People
- Alun Thomas
Organizations
- University of Utah